Mexiletine-theophylline interaction

Mexiletine on segmental hyperhidrosis.

Interaction between theophylline and tacrolimus in a renal transplant patient.

5–15 ng/ml). In May 1998, the patient developed post-renal-transplant erythrocytosis. Hb and Hct values rose to 19.4 g/dl and 54% respectively. WBC remained within

Theophylline

Theophylline (3-methyxanthine) has been used to treat airway diseases for over 70 years. It was originally used as a bronchodilator but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β₂-agonists became more widely used. More recently it has been shown to have anti-inflammatory effects in asthma and COPD at lower concentrations. The m...

Mexiletine clearance during peritoneal dialysis.

infant would receive approximately 1.5 mg of disopyramide per day assuming a generous intake of 1 1 of milk. Even taking into account the two fold variability in breast milk levels of disopyramide reported by Barnett et al. (1980), the maximum amount of drug transmitted to the infant would be 3 mg/day (0.6% of the maternal dose). The manufacturer's product information recommends, on the basis o...

Mexiletine-quinidine combination: electrophysiologic correlates of a favorable antiarrhythmic interaction in humans.

Combination therapy with mexiletine and quinidine has been shown to be more effective than either agent alone. The ability of mexiletine monotherapy, quinidine monotherapy and mexiletine-quinidine combination therapy to suppress inducible sustained ventricular tachycardia was related to drug-induced changes in ventricular refractoriness, conduction times and monophasic action potential duration...